4/15/2023 0 Comments Dvdfab crack 10.0.2.8![]() Highly conserved from fish to humans, Ecrg4 encodes a 148 amino acids precursor protein that can be processed into various peptides, without identified regulatory proteases. ![]() We have previously identified the Ecrg4 gene as upregulated in hypercalciuric mice. Thus, hypercalciuria and hyperoxaluria are two major risk factors for crystallogenesis in urine. In both conditions, supersaturation of calcium-oxalate salts and crystal formation may result either in obstruction of renal tubules or in stone formation. Prevalence of chronic kidney diseases and of kidney stones is constantly increasing. This promotes Ecrg4 as a modulator of renal crystallization and may open the way to new therapeutic possibilities against calcium oxalate nephropathy. Taken together, our study demonstrates that Ecrg4’s expression is restricted mainly to the distal part of the nephron and that the Ecrg4 KO mice develop less signs of tubular obstruction and less calcium-oxalate deposits. For this, Ecrg4 KO mice were challenged with a kidney stone-inducing diet, rich in calcium and oxalate precursor. In this study, we have first (i) validated the increased Ecrg4 mRNA in several types of hypercalciuric mouse models, then (ii) described the Ecrg4 mRNA expression along the nephron and (iii) assessed ECRG4’s putative role in calcium oxalate nephropathy. We hypothesized that the increased expression of Ecrg4 mRNA is triggered by hypercalciuria and might modulate intratubular calcium-oxalate precipitation. To the best of our knowledge, nothing is known about ECRG4’s function in the renal tissue and its relationship with calciuria. ![]() Lately, it was shown to be involved as well in apoptosis, cell senescence, cell migration, inflammation and cell responsiveness to chemotherapy. Ecrg4 was initially described as a tumor suppressor gene in the esophagus. We have previously identified Esophageal cancer-related gene 4 ( Ecrg4) as being modulated by hypercalciuria. Kidney stones are the result of salt supersaturation, including calcium and oxalate. Kidney stone is one of the most frequent urinary tract diseases, affecting 10% of the population and displaying a high recurrence rate.
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